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Pulmonary biocompatibility assessment of helical rosette nanotubes

W.S. Journeay, H. Fenniri and B. Singh
University of Saskatchewan, CA

Keywords:
toxicology, lungs, drug delivery, rosette nanotubes, biocompatibility

Abstract:
Helical rosette nanotubes are a class of organic nanotubes synthesized through the self-assembly of individual rosettes. These compounds have potential for custom drug delivery platforms. To date, there are no in vivo data on the biocompatibility of this class of organic nanotubes. We have chosen a lysine-conjugated nanotube and investigated the nanotubes’ compatibility in the lungs of C57/BL mice. This work is aimed at determining the in vivo compatibility of the lysine-conjugated compound and eventually to determine appropriate doses of the compound via pulmonary and other routes. Here we have examined markers of pulmonary inflammation after doses of 5,25,& 50ug of a specific lysine conjugated helical rosette nanotube. Preliminary data indicate that the 25 & 50 ug dose induce an inflammatory response in the mice at 24h post-exposure while the 0.1ug dose appears to be well tolerated by the animals. Future, endpoints will include cytokine protein and mRNA expression as well as adhesion molecule expression at 24h and 7d.

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