Phosphorylcholine-protected Nanoparticles Functionalized with Both Magnetic and Photoluminescent Properties
Y.C. Chung and C.J. Chen
National University of Kaohsiung, TW
nanoparticle, biocompatible, endocytosis
We prepared the magnetite core coated with nano-graded ZnS shell to display superparamagnetic and photoluminescent properties. By adsorbing the phosphorylcholine-ended thiol to stabilize the core-shell nanoparticles, the particles can be well-dispersed in aqueous buffer solution for a long term and display weak interaction with proteins. The superparamagnetic magnetite was synthesized using ferric chloride and sodium sulfite mixture and gathered via magnetic precipitation and centrifugation. The magnetite pre-adsorbed with zinc acetate overnight was then dispersed and reacted with thioacetamide using ultrasonic horn (100 W, Branson) in deionized water at 80 °C for 3 h, giving the thin zinc sulphide layer. Furthermore, the phospholipid derivative, 11-mercaptoundecylphosphorylcholine (SPC), derived from our previous investigation was to stabilize the outmost ZnS surfaces of nanoparticles.
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Nanotech 2005 Conference Program Abstract