Directed Self-Assembly of Virus-Based Hybrid Nanostructures
C. Tsai and C.S. Ozkan
University Of California, Riverside, US
biological self assembly, functional carbon nanotubes
Application of biomolecules in self-assembly has an advantage to produce functional building-block for bottom-up approach in nanofabrication. Well known unenveloped viruses such as poliovirus (PV) and tobacco mosaic virus (TMV) were used in our self-assembled nanostructure. Icosahedral PV and cylindrical TMV particles provides different geometric options for heterostructure assembly along with their well characterized surface properties and nanoscale dimensions. 1-Ethyl-3-(3-dimethyl aminopropyl)-carbodiimide (EDC) coupling was applied for covalent conjugation between organic virus capsid and functionalized inorganic nanoparticles such as single-walled carbon nanotubes (SWCNT) or quantum dots (QD). We have demonstrated several building blocks using EDC coupling such as SWCNT with PV particles and carboxylated QDs with TMV particles to form heterojunctions in nanoscale self-assembly. By taking advantage of the receptor recognition to its virus counterpart, we’ve also shown that antibody functionalized nanoparticles (SWCNTs, QDs, and Pt particles) attached only to where the virus counterpart was. In this case, directed and selective hybridization of hetero-nanostructures can be implemented. While using viruses as linkers, we can selectively make conductive interconnects by metallizing virions with metal particle functionalized antibodies which open an avenue to bio-nanoelectronics.
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Nanotech 2005 Conference Program Abstract