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Formation of Nanoparticles of a Hydrophilic Drug using Supercritical CO2 and Microencapsulation for Sustained Drug Release

A.J. Thote and R.B. Gupta
Auburn University, US

Keywords:
sustained, controlled drug release, dexamethasone phosphate, PLGA, SAS-EM, s/o/o/o

Abstract:
The problem of initial burst release, in sustained drug delivery devices was resolved by reducing the active pharmaceutical ingredient particle size by using Supercritical Antisolvent technique with Enhanced Mass-transfer (SAS-EM)., Encapsulation was performed using a nonaqueous s/o/o/o technique giving high encapsulation efficiencies for hydrophilic drugs. Using SAS-EM, dexamethasone phosphate nanoparticles were obtained in the range of 150-200 nano-meter. Upon encapsulation in PLGA, composite microspheres of ~70 micro-meter were obtained with about 90% drug encapsulated. The in-vitro drug release study of these microparticle/nanoparticle composites showed sustained drug release over 700 hours with negligible burst release.

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