Intracellular Uptake of Folate Receptor Targeted Superparamagnetic Nanoparticles for Enhanced Tumor Detection by MRI
C. Sun, O. Veiseh, N. Kohler, J. Gunn, D. Lee, R. Sze, A. Hallahan and M. Zhang
University of Washington, US
magnetic resonance imaging, contrast agent, iron oxide nanoparticles, PEG, folic acid, tumor imaging
Tumor specific superparamagnetic nanoparticle conjugates are currently being developed as targeting-contrast agents for magnetic resonance imaging (MRI). The application of such “smart” molecular imaging probes will have a significant clinical impact as a non-invasive method of cancer detection and diagnosis. In this study, we examine the vitamin folic acid (FA) as a targeting agent for the delivery of superparamagnetic nanoparticles to specific tumor cells in vitro. Results from this study suggest that the synthesized FA-superparamagnetic nanoparticle conjugates can be used to target specific tumor cells for detection by MRI.
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Nanotech 2005 Conference Program Abstract