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Electronic Sensing of Antibodies using Carbon Nanotube Devices

K. Teker, K. Sivakumar, E. Wickstrom and B. Panchapakesan
University of Delaware, US

Keywords:
nanotube field effect transistors, electronic sensing, antibodies, HER2, confocal microscopy.

Abstract:
Carbon nanotubes (CNTs) are remarkable solid state nanomaterials due to their unique properties such as high surface area, hollow cavities, and excellent mechanical and electrical properties. Interfacing carbon nanotubes with biological materials could enable significant advances in biomedical applications such as disease diagnosis and treatment. In addition, the bioconjugated nanotubes combine with the sensitive nanotube-based electronic devices would enable sensitive biosensors toward medical diagnostics. This paper presents electronic sensing of antibodies that are specific to HER2 surface receptors in cancer cells with nanotube field effect transistor devices. This paper also presents antibody functionalization of carbon nanotubes and its potential applications for breast cancer diagnostics.

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