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Peptidic Nanoparticles for Cancer Therapy and Diagnosis

A. Graff, D. Tropel, SK. Raman, G. Machaidze, A. Lustig and P. Burkhard
University of Basel, CH

Keywords:
peptidic nanoparticles, somatostatin, drug targeting, drug delivery

Abstract:
Somatostatin peptides such as somatostatin 28 or 14 are known for their high binding affinity to G-coupled peptide receptors, which are often over-expressed on tumor cells. Using this binding property we developed a new type of functional peptidic nanoparticles based on Somatostatin for tumor targeting and drug delivery. Somatostatin 28 and 14 were genetically incorporated into the nanoparticles and in addition they will be radiolabeld with radionuclides (technetium-99m for example). Because targeting peptides can easily be introduced into the sequence of the nanoparticles forming peptide, this new technology can be regarded as a plattform for the design of a variety of tumor-targeting motifs.

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