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Reconstruction of Load-Bearing Defects in Oncology by Using Nanomodification of Implants

V.I. Chissov, I.V. Reshetov, E.A. Levashov, D.V. Shtansky, M.M. Filushin, S.S. Sukharev and I.A. Bashkova
Moscow Research Oncological Institute, RU

Keywords:
reconstructive, operations, nanostructured, coatings, implants, biocompatibility

Abstract:
By means of nanotechnological approach different coating procedures enlarging biocompatibility factors of implants were developed. The well-known materials – titanium plates are used as substrates supporting structures. Depending on the construction type (stable or rolling) different nanostructured thin films and coatings in the system Ti-(Si, Ca, Zr)-(C, N, O, P) are applied using magnetron sputtering and ion implantation assisted magnetron sputtering techniques. By changing the composition, as well as the surface structure of coatings one can effect both massive and thin fibrogenesis on the implant’s surface The effectiveness of implants considered in comparison with a control group of implants without nanostructured modification is proved by experimental models The use of nanostructured modification of medical implants can genuinely influence and provide control over the processes of biointegration. The combination of excellent mechanical properties with biocompatibility and non-toxicity makes nanostructured films promising candidates to be used for various medical applications.

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