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A Microfluidic System for Continuous Magnetophoretic Separation of Suspended Cells Using Their Native Magnetic Properties

K-H Han and A. Bruno Frazier
Georgia Institute of Technology, US

Keywords:
magnetophoresis, microseparator, cells, microfluid

Abstract:
This paper presents the characterization of a continuous magnetophoretic microseparator for separating white and red blood cells from whole blood by using a high gradient magnetic separation method and microfabrication technology. The magnetophoretic microseparator directly separates blood cells based on their native magnetic properties without the use of additives such as magnetic tagging or inducing materials. Early released experimental results show that within 5 minutes, the microseparator can continuously separate out 68.2% of the red blood cells from whole blood for the paramagnetic capture (PMC) mode, and 89.7% for the diamagnetic capture (DMC) mode, by applying an external magnetic flux of 0.2T using a permanent magnet.

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