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Pore Size Control of New Liophilized Nanobiomaterials for Tissue Engineering

M. Vallet-Regí, J. Peña, A. Larena and D.A. Cáceres
E T S Industrial Engineering, ES

Keywords:
biomaterials, lyophilization, pore size

Abstract:
Biopolymers have potential applications as prosthesis and tissue substitutes. In vitro biocompatibility of some of them has been demonstrated (Larena, Cáceres, De la Piedra, Montero, Vicario, Fuentes, Ibarzábal, Bernabeu and Ribelles, 2004). Lyophilization can improve pore sizes of new nanobiomaterials, and with a addition of porogens, the pore size control could be achieved. However for Tissue Engineering a sterilization of biomaterials is necessary. The goals of present work requieres pores size measurement and control by means of MIP and BET techniques and the changes observed when a sterilization process in applicated in new polymeric nanobiomaterials. For morphology observation SEM and polarization microscopy are used. Water retention of the materials can complete the pore size characterization.

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