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Modeling of Cellular Communication by Means of Petrinets

I. Barjis, S. Berri and J. Barjis
New York City College of Technology, The City University of New Tork, US

Keywords:
petrinets, G-proteins, cAMP, modeling, cellular communication

Abstract:
This paper introduces application of Petri nets to molecular biology. In particular, it illustrates how by means of Petri nets the process of cellular communication can be modeled, and analyzed, where the model could be used for the research purpose and/ or teaching purposes. In order to develop a Petri net model for the process of cellular communication, firstly the paper explains molecular reactions of the processes (G-Proteins and cAMP), because the validity of the developed model depends on how well the real processes are identified and highlighted. Since the emphasis of this paper is on application of Petri net rather than the underlying molecular aspects, the molecular and biological events and reactions are not covered in very depth. Only the most important molecular events of the process of cellular communication, needed as an input data for building a Petri net model, are described. The Petri net model is developed using Colored Petri net tools (CPN), which allows graphical editing, analysis and simulation of Petri net models.

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