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Bioelectronic Nanoscale Ion Channel Array Stabilization and Active Readout based on Quantum Resonance Interferometry

S. Gulati
ViaLogy Corp., US

Keywords:
bioelectronic nanoscale ion channel array stabilization, active readout, quantum resonance interferometry

Abstract:
We will present an overall systems approach to fabrication of ion-channel array which includes silicon processing, utilization of an AFM based dip-pen nanolithographic (DPN) approach for depositing the individual lipid bilayers and ion channels, a novel polymerization technique to create stable bilayers, selection of biochemical assays for inline detection of ion-channel degradation and partial reconstitution and a novel ultra-weak signal processing technique for detecting ion-transport even with significant channel functional degradation and variation in diffusion efficacy and ion flux rates. Specifically, this presentation will focus on the computational readout backplane based on implementation of quantum resonance interferometry (QRI) for ultra-weak signal detection and amplification technology. QRI is inspired by class of algorithms based on stochastic resonance, where it has been shown that the exploitation of classical noise injection to a dynamical system can increase signal-to-noise ratio (SNR) (Benzi ¡¯81). QRI uses complex noise (derived from simulations of systems with underlying quantum mechanical noise) injection to exploit quantum stochastic resonance (QSR) phenomenology to achieve SNR. This active signal processing technique has been extensively validated on high density microarrays, spotted arrays, protein expression systems, and fluorescence imaging assays. The scientific principals underlying the platform technology – quantum resonance Interferometry (QRI), are analogous to optical interferometry, quantum interferometry and active radar imaging, which enable dramatic improvements in ultra-weak signal imaging. Interferometry techniques have been previously used to measure very small differences in lengths, distances and changes in dimension density and other properties by the interference of two waves of light for optical imaging and communication applications. QRI is exploiting interference between a mathematically transformed, ion-flux signal output from an open ion-channel and an external synthetic stimulus. In a biomarker detection application, the ion channel characteristics are used to construct the external synthetic stimulus. A resonance pattern is generated by iteratively convolving the output flux with the external stimulus.

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