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Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
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Cellular Response to Nanoparticle Exposure

G.W. Erdos, D. Moraga, M. Palazuelos and K. Powers
University of Florida, US

Keywords:
toxicology,apoptosis,lysosomes,electron microscopy

Abstract:
Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak cytochrome-c which begins a process leading to apoptotic cell death.

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