Cellular Response to Nanoparticle Exposure
G.W. Erdos, D. Moraga, M. Palazuelos and K. Powers
University of Florida, US
Keywords:
toxicology,apoptosis,lysosomes,electron microscopy
Abstract:
Cells exposed to particles will phagocytose them and shuttle the endosomes to lysosomal compartments. Lysosomal mebranes rupture, possibly due to free radical formation. Proteases are released which inturn compromise the mitochondrial membranes. The mitochondria leak cytochrome-c which begins a process leading to apoptotic cell death.
Back to Program
Nanotech 2005 Conference Program Abstract
| 
