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Carbon Coated Magnetic Nanoparticles for Local Drug Delivery using Magnetic Implants

R. Fernández-Pacheco, M.R. Ibarra, J.G. Valdivia, C. Marquina, D. Serrate, M.S. Romero, M. Gutiérrez and J. Arbiol
Institute of Nanoscience of Aragon, ES

Keywords:
magnetic nanoparticles, magnetic implants, local therapy

Abstract:
Bioferrofluid obtained using iron coated nanoparticles are promising candidates for magnetic drug delivery. The carbon cages made the particles biocompatibles and provide a suport for drug adsortion. We propose a new method in which gold plated permanent magnets are implanted close to the tumor by using endoscopic techniques in the affected organ. The bioferrofluid charged with the chemiotherapic is injected and the particles are attracted to the magnet and desorption of the drug take place at the tumoral región. This method has advantages over the aplication of external fields being more effective and also avoiding the need to be at the place of the big external magnets. We report the procedures to obtain the bioferrofluids and in-vitro experiments. In vivo experiments performed on rabits revealed the reliability of this method.

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