Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Program
Sessions
Sunday
Monday
Tuesday
Wednesday
Thursday
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Conferences
Sponsors
Exhibitors
Venue 2005
Organization
Press Room
Subscribe
Site Map
 
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461
E-mail:
 
 

Characterization of a Tethering System for Biosensor Applications

L. Blasi, P.P. Pompa, D. Pisignano, G. Palazzo, A. Mallardi, G. Maruccio, A. Maffei, G. Ciccarella, G. Vasapollo, F. Calabi, R. Cingolani and R. Rinaldi
Leece University, IT

Keywords:
dopaminergic receptors, tethered bilayer, scanning probes microscopy, fluorescence spectroscopy

Abstract:
The immobilization of brain dopamine receptors on a solid support can represent an appealing strategy for the realisation of a sensing element for dopamine and dopaminergic drugs. Brain dopamine receptors are the primary targets in the treatment of schizophrenia, Parkinson’s disease, and Huntington’s chorea. Our final goal is the realization of an optical biosensor which allows a parallel quantitative analysis, with different receptors, of neurotransmitters and different drugs related to the pathologies of interest. The active layer will be constituted by dopaminergic receptors immobilized in biomimetic membranes. The need to preserve the biological activity of neuroreceptors is dramatically important and requires that the protein of interest has to be reconstituted into lipid bilayers tethered to a suitable sensor surface. Such processes involve the fabrication of artificial tethered bilayer (biomimetic membranes), the immobilization of the receptors in these membranes by soft lithography methods. The characterization of the active layer was performed by scanning probe techniques, in order to test its quality and integrity, and by suitable optical experiments involving the intrinsic fluorescence of the neurotransmitter (or neuroreceptors), or the signal emitted by specific fluorescent ligands

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

 
Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community
 
 

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact