Enhancement of E6 Protein Binding on Binding-Orientation-Sensitive Mixed SAMs Molecules
F.G. Tseng, J.K. Hwang, S.W. Hung, J.M. Chang, T.W. Huang, Y.T. Tseng, H.M. Huang and C.C. Chieng
National Tsing Hua University, TW
mixed SAMs, binding, protein, molecular dynamics simulation, atomic force microscopy
Orientation selectivity and binding enhancement with E6 protein are demonstrated by nano-structured mixed-SAMs systems of different chain lengths. Mixtures of n-alkinethiol SAMs of different chain lengths: 1-Decanethiol (C9) and 1-Hexanethiol (C5) are the examples in present work The demonstrations include the molecular dynamics simulations on the binding energies of a single E6 protein molecule with mixed SAMs molecules and the binding force measurements by Atomic Force Microscope (AFM) for a cluster of E6 protein molecules at different orientations with the same SAMs.
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Nanotech 2005 Conference Program Abstract