Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Program
Sessions
Sunday
Monday
Tuesday
Wednesday
Thursday
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Conferences
Sponsors
Exhibitors
Venue 2005
Organization
Press Room
Subscribe
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461
E-mail:
 
 

Superparamagnetic Iron Oxide-Gold Core-Shell Nanoparticles for Biomedical Applications

G. Saini, D. Shenoy, D.K. Nagesha, R. Kautz, S. Sridhar and M. Amiji
Northeastern University, US

Keywords:
iron oxide-gold, nanoparticles, biomedical

Abstract:
Iron oxide nanoparticles (NPs) in the form of maghemite and magnetite have been used for targeted drug delivery, magnetic cell sorting, magnetic resonance imaging (MRI) contrast agents and immunoassays. Surface modification of these NPs is one approach to enhance their biomedical applications. We have prepared a Fe2O3 NPs with a thin coating of gold to form a core/shell system. The Fe2O3 core was prepared by oxidizing Fe3O4 NPs formed by the co-precipitation of Fe(II) and Fe(III) salts in alkaline medium. The gold shell was formed by the reduction of Au3+ on iron oxide surface by the iterative hydroxylamine method. The NPs were characterized by UV-Vis absorption spectroscopy and transmission electron microscopy (TEM). SQUID magnetometry revealed that the superparamagnetic property of the NPs was not affected by the presence of Au shell. The potential use of these NPs as MRI contrast agents was investigated by monitoring the T2 relaxation time of the NPs at various concentrations. The preliminary results show a linear dependency of T2 relaxation time with concentration. Cytotoxicity of these NPs was studied by monitoring cell viability and proliferation in the presence of NPs. The bioconjugation protocols used for gold can be extended to these Fe oxide/Au shell NPs. These initial results and presence of gold coatings opens the door for a variety of applications for the Fe oxide/Au core-shell NPs.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

 
Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community
 
 

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact