Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Program
Sessions
Sunday
Monday
Tuesday
Wednesday
Thursday
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Conferences
Sponsors
Exhibitors
Venue 2005
Organization
Press Room
Subscribe
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461
E-mail:
 
 

Circulating Tumor Cells: Capture with a Micromachined Device

H. Mohamed, M. Murray, J.N. Turner and M. Caggana
New York State Department of Health, US

Keywords:
biochips, cell sorting, circulating tumor cells, cancer

Abstract:
The isolation and analysis of circulating tumor cells (CTCs) from blood is the subject of intense research. Tests to detect metastasis are available but progress is hampered by the lack of tumor-specific markers and predictable DNA abnormalities. CTCs from solid tumors can be separated from normal hematopoietic cells based on size and other inherent physical and biological properties. The main challenge in this endeavor is the small number of available cells of interest, 1-2 per ml in human whole blood. A micromachined device for fractioning whole blood using physical methods to enrich and/or isolate rare cell types from peripheral circulation was designed. It has four segments of microfluidic channels, each consisting of a 2-D array of columns. The gap between the columns narrows as cells traverse the device. Current devices have channels ranging in width from 20mm-5mm, and in depth from 20mm-5mm. When adult blood, spiked with cells from eight cancer cell lines was loaded into the device, all cancerous cells were retained in a well-defined area of the device while blood cells migrated to the output reservoir. These studies will advance non-invasive methods to monitor patients, stage disease, and assess treatment. Furthermore, insights into metastasis will be gained.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

 
Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community
 
 

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact