Ion Sources for Biomolecules with Controlled Superposition of Electric and Pneumatic Fields
Ciphergen Biosystems, Inc., US
MALDI, proteomics, ion source, ion temperature, collisional cooling, GEMIOS, ANSYS, simulation
As previously reported the design of advanced ion sources for collisionaly cooled biomolecules required the development of an advanced multi-physics simulation system GEMIOS (Gas and Electromagnetic Ion Optical Simulator). Recent research based on such GEMIOS simulations led to the creation of the term ''electro-pneumatic ion optics'' since the functionality of considered novel ion-optical devices is in fact based on the superposition of at least two vector fields and one scalar field. Specifically, and in contrast to state-of-the art devices, gas pressure and gas flow velocities are not considered as global quantities but true field solutions are obtained. As a result, collision frequencies and momentum transfer vary spatially. This allows the design a of new class of electro-pneumatic devices in which elements act as electrodes as well as nozzles or wings and in which the balance between electrical and collisional forces varies locally in a controlled fashion.
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Nanotech 2005 Conference Program Abstract