Nanostructured Membrane for Implantable Nanobiosensor
University of South Florida, US
nanomaterial, nanoparticles, implantable nanobiosensor
Years from now, a typical doctor visit might not required a chip implanted in the body will function as a constant on-board doctor, detecting diseases early and delivering drugs straight into the bloodstream. Nanobiosensors could make this scenario a reality before your toddler goes to college. Implantable biosensors have many drawbacks such as allergic response, cells growth over the device and rejection due to immune response of our body which can be greatly improved by using modified membrane. This requires the use of a novel coating material on the biosensor surface that reduces the protein adsorption and the subsequent inflammatory response. Our concept in solving this protein deposition problem is by exploiting a novel nanostructured membrane coating over the interface-surface of implantable sensor applications, which composes of an optimized biocompatible membrane template coated with protein resistant layers of advanced nanostructures. The nanostructured membrane will control the tissue/ sensor interface interaction. Further this can be improved by using a protein-resistant nanostructured membrane, evaluate its physical properties, and confirm the improved functional performance in sensor applications. This nano-approach includes 1) A semi-permeable membrane template with optimized & physiologically compatible structures for precise control of molecular diffusion and interphase interaction. (2) A nanostructured coating system composed of silica nanoparticle cores and high density functional polymer brushes, chemically grown from the silica nanoparticle cores, resisting protein adsorption and improving coverage and binding ability of the functional components (3) An integrated membrane coating system for protein deposition prevention and the subsequent tissue response minimization. (4). A composite membrane with the requisite transport properties for analytes only. The experiments related to present approach are in progress in our laboratory.
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Nanotech 2005 Conference Program Abstract