Biochips for Genetic Sample Preparation: From Micro- to Nano- Analytical Environments

P. Grodzinski
Los Alamos National Lab, US

Keywords: bio chip, genetic, sampling, sensing

Abstract:
In this presentation, we will discuss a development of plastic, disposable chip sets for genetic sample preparation and cell pre-concentration. To assure assay flexibility of the analytical system, the assay functions from rare target (cell) capture and concentration through cell lysing, DNA amplification and DNA interrogation using hybridization arrays, are included on the chip. The individual chip assay components, the fabrication techniques, as well as sample transport techniques and component integration schemes will be also described. In the second part of the talk, we will introduce DOE Center for Integrated Nanotechnologies (CINT), joint effort between Sandia and Los Alamos National Laboratories. The central scheme of the center is the integration and interfacing of materials and functionalities, from both organic and inorganic worlds, over the range of length scales. The scientific interests of the center span over five thrusts focused on nano-bio-micro interfaces, nanophotonics and nanoelectronics, nanomechanics, complex materials, and theory and simulation. The center operates as a national user facility providing access to state-of-the-art facilities staffed by laboratory scientists, post-doctoral fellows and technical support personnel.

Nanotech 2004 Conference Technical Program Abstract