An Integrated Transport Model for Tracking of Individual Exocytotic Events Using a Microelectrode
T-H Fan and A.G. Fedorov
Georgia Institute of Technology, US
Keywords: exocytosis, neurotransmitter, biotransport, microelectrode
A complex biophysical process underlying the release of neurotransmitters and hormones from the secretion cells, known as a vesicular exocytosis, is an important mechanism that defines cell signaling and intercellular communication. This phenomenon has been continuously drawing attention of neuroscientists and physiologists because an abnormal regulation of the cell signaling process may cause many human diseases. In this paper, we focus on modeling of the vesicle post-fusion step of the exocytotic sequence aiming at resolving the biophysics of the process at the micron/submicron scale. The simulation results are qualitatively compared with the experimental results from the literature of the in vivo electroanalysis.
Nanotech 2004 Conference Technical Program Abstract