Lattice Boltzmann Simulations Comparing Conventional and a Heat Conduction Based Flow-Through PCR Micro-Devices
SPAWAR Systems Center San Diego, US
Keywords: lattice Boltzmann, PCR, microfluidics, simulations
This paper describes the lattice Boltzmann, numerical simu-lations used to evaluate a conduction-based, polymerase chain reaction (PCR) device for uniformity of the micro channel temperature profile and its velocity field distribu-tion. For comparison purposes, numerical simulations were also performed using conventional PCR configurations. The simulation results demonstrate that in two-dimensions adequate performance of both the conventional and the heat conduction-based PCR systems. However, three-dimensional results indicate that nearly uniform wall tem-peratures (top, bottom and sides) are required to obtain uni-form temperature fields in the PCR micro channels.
Nanotech 2004 Conference Technical Program Abstract