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Modelling and Optimization of Medical Test Strips Made From Plastics

O.Nuessen, D.Peters, H.Bolte and R.Laur
University of Bremen, DE

Keywords: CAD, Microfluidics, Modelling, Simulation, Optimization, MEMS Design, Medical Test Strips

Abstract:
Introduction In cooperation with industrial partners, a behavioural model for the microsystem ‚Medical Test Strips‘ has been created by the authors in order to decrease cost and effort in the design process. As there is no complete theory for the underlying system yet, with capillar interaction between up to three different materials, the flow of liquids in such an application cannot be described analytically. Medical Test Strips made from plastics are an innovative approach towards cheap and therefore seminal one-way diagnostic systems and can be considered as a step towards the long discussed ‚lab on a chip‘. Main field of application is the analysis of body liquids as blood and urine in regard to the diagnose of antibodies for certain diseases or the examination of particular characteristics. The system mainly consists of microchannels, structured with small columns or lamellae to increase the fluidic resistance (Fig.1,2). Quantities of interest are the volume flow and the filling time of the channel, related to the system geometry and material properties. They determine the retention period of the liquid and therefore the time for chemical reactions as essential parameters concerning functionality.

NSTI Nanotech 2003 Conference Technical Program Abstract

 
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